St. Jerome’s Roman Catholic Church was the city of Holyoke’s first Catholic church. Holyoke Catholics were first organized in 1856 and the church, located at 181 Hampden Street, was built in 1858-1860. The church was designed by prominent church architect Patrick Keely. A fire in 1934 destroyed everything but the church’s brick walls. The building was rebuilt to plans by John W. Donahue of Springfield. A chapel was added to the rear of the church, plans starting in 1939.

Next to the church is the parish rectory, at 169 Hampden Street. Built in 1869, it is a French Second Empire-style building with a Mansard roof.