The Isaac S. Parsons House is an Italianate residence, built in 1860 at 4 Park Street in the village of Florence in Northampton. The house was designed by E.C. Gardner, who was an architect and author. Originally from Florence, he later settled in Springfield. Isaac S. Parsons ran a store, I. S. Parsons & Co., on Nonotuck Street and became Florence’s first postmaster in 1852, a position he held for 16 years. He was an organizer of the Florence Manufacturing Company. The house was sold in 1889 to Henry F. Cutler, one of the owners of Cutler, Plympton and Co., a grocery and dry goods business. Cutler was also post master. The house has lost its original Italianate cupola.