The Divine Liturgy of St. John Chrysostom was celebrated for the first time in Holyoke in 1911 and Greek Orthodox services began to be regularly held in the city by 1914. Holy Trinity Greek Orthodox Church was built in 1916-1917. Two decades later, the mortgage for the church was retired. The Consecration of the edifice, located at 410 Main Street, took place on November 30, 1938. The church was designed by the well known Greek architect, Kyriakos Kalfas of New York City. He modeled its Byzantine design on that of the Church of the Pantocrator in Patras, Greece. A fire on January 31, 1977 extensively damaged the church, but rebuilding process soon began. Services resumed in the church by July 1978 and the building was consecrated again on October 7, 1979.